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With Little Data, Doctors Struggle to Decide Which Covid-19 Patients Should Get Remdesivir(STAT) Now that the federal government has begun distributing the experimental Covid-19 drug remdesivir, hospitals are in a bind. So far, it’s the only medication that has shown benefit for coronavirus patients in rigorous studies. But there isn’t enough for everyone who’s eligible. That leaves doctors with a wrenching ethical decision: Who gets the drug, and who doesn’t?
Public & Global Health
COVID-19 and Postinfection Immunity, Limited Evidence, Many Remaining Questions(JAMA) Understanding whether and how recovery from COVID-19 confers immunity to, or decreased severity of, reinfection is needed to inform current efforts to safely scale back population-based interventions and has important implications for epidemiologic assessments, serologic therapies, and vaccines. This article describes what is currently known about the immune response to COVID-19, highlight key gaps in knowledge, and identify opportunities for future research.
Preliminary Estimate of Excess Mortality During the COVID-19 Outbreak — New York City, March 11–May 2, 2020(CDC MMWR) Counting only confirmed or probable COVID-19–associated deaths likely underestimates the number of deaths attributable to the pandemic. The counting of confirmed and probable COVID-19–associated deaths might not include deaths among persons with SARS-CoV-2 infection who did not access diagnostic testing, tested falsely negative, or became infected after testing negative, died outside of a health care setting, or for whom COVID-19 was not suspected by a health care provider as a cause of death.
WHO Tackles Reopening Issues, Posts COVID-19 Guidance for Schools, Workplaces(CIDRAP) As more countries took further steps at easing COVID-19 restrictions this week, some that are further along in the process are battling clusters and upticks in cases, as the World Health Organization (WHO) released new guidance on reopening schools and workplaces. The WHO today also warned that disruptions related to the COVID-19 battle could hurt the battle against HIV.
Ethics and Governance for Digital Disease Surveillance(Science) Focusing on core public health functions of case detection, contact tracing, and isolation and quarantine, we explore ethical concerns raised by digital technologies and new data sources in public health surveillance during epidemics.
Respiratory Disease in Rhesus Macaques Inoculated with SARS-CoV-2 (Nature) The rhesus macaque recapitulates moderate disease observed in the majority of human cases. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease and will aid development and testing of medical countermeasures.